Pathogenic accumulation of amyloid-β (Aβ) peptide, caused by an imbalance of anabolic and catabolic activity in the brain, is believed to trigger Alzheimer’s disease (AD). Identified familial mutations on APP, PSEN1, and PSEN2 genes induce excessive production of toxic Aβ species, such as Aβ42 and Aβ43, or alter the Aβ42/40 ratio, leading to Aβ deposition […]